Small intestine cancer is the malignancy of the cells in the small intestine, also called small bowel, which is a narrow tube in the digestive tract that connects the stomach to the large intestine. Small intestine cancer is rarer than other forms of bowel cancer, such as cancer of the large intestine and rectal cancer. The most frequent form of small intestine cancer is adenocarcinoma. Other rarer types include lymphoma, carcinoid and gastrointestinal stromal tumour.

The most common risk factors for small intestine cancer are thought to be Crohn's disease, Celiac disease, exposure to high levels of radiation, genetic conditions such as familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer and Peutz-Jeghers syndrome.

Small intestine cancer patients rarely display early symptoms. Later symptoms may include discomfort in the abdomen, bloating, nausea, loss of appetite, bleeding from the back passage, tiredness, weight loss and anaemia (low level of haemoglobin in the blood), yellow skin and eyeballs. Severe vomiting and bleeding may indicate that the tumour has blocked the passing of waste through the small intestine, in which case urgent medical attention is necessary.

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